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Close to 70% of patients with lung cancer present with locally advanced or metastatic disease at the time of diagnosis.

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Patients with severe renal impairment should be treated with caution when given IRESSA.

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En el primer ensayo, 230 pacientes a los que no se les administró quimioterapia con CPCNP metastásico y mutaciones EGFR se asignaron de forma aleatorizada para recibir gefitinib o una combinación de carboplatino-paclitaxel.

Clinical experiences with molecular targeted therapy in lung cancer in China.

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Imatinib is to be used only by the patient for whom it is prescribed.

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Both these patients had SCC and a PS of 3, and no improvement in either patient had been observed during gefitinib treatment.

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Addressing the unmet need in lung cancer: The potential of immuno-oncology.

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FISH) is viewed as being the "gold standard" technique in identifying patients who would benefit from trastuzumab, but it is expensive and requires fluorescence microscopy and an image capture system.

Preexisting immune status and its modification by treatment also seem necessary.

HER2 treatments, including trastuzumab, is cardiac in nature, ie, a decrease in left ventricular ejection fraction.

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Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.

In patients with symptomatic increased ICP (ie, severe intractable headache, papilledema, stupor, and repetitive plateau waves on EEG), placement of a ventriculoperitoneal (VP) shunt may be necessary if the increased ICP is not ameliorated by steroids.

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Not all side effects for gefitinib may be reported.

Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, et al.

CSF vascular growth factor has recently been suggested as a useful biomarker.

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High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression.

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Mutations in the kinase domain of epidermal growth factor receptor (EGFR) are associated with clinical responsiveness to gefitinib in patients with non-small-cell lung cancers (NSCLC).

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The intent at this stage is to extend survival time, rather than cure the disease.

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For measurement of proliferation, 10 000 control or gefitinib-resistant cells were plated in 500 μl RPMI 1640 containing 10 % fetal bovine serum in 24-well plates or 20 000 HCC2279 control or gefitinib-resistant cells were plated in 1 ml RPMI 1640 containing 10 % fetal bovine serum in 12-well plates.

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Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small cell lung cancer.

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Recently, many studies have been performed to determine precisely how to select patients who will respond to gefitinib, the best timing for its administration, and how to avoid the development of acquired resistance as well as adverse drug effects.

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BACKGROUND: Gefitinib is widely used in patients with advanced non-small-cell lung cancer (NSCLC), in whom chemotherapy had failed.

También se agregó que, de manera similar al análisis de la supervivencia sin avance (SSA), la SG se estratificó según el tipo de mutación en EGFR y el origen étnico.

Although radiation damages both cancer cells and normal cells, most normal cells can recover from the effects of radiation and function properly.

Vehicle and gefitinib were given once per day, five times per week, by gavage.

Desch CE, Benson AB 3rd, Somerfield MR, et al: Colorectal cancer surveillance: 2005 update of an American Society of Clinical Oncology practice guideline.

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The appropriate dose and schedule of gefitinib readministration also should be determined in these trials.

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Unfortunately, ceasing to take the inhibitor may be the only reversal strategy of the unfavorable symptoms.

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Chemotherapy-induced diarrhea (CID) is a common problem, especially in patients with advanced cancer.

Options for the treatment of gemcitabine-resistant advanced pancreatic cancer.

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This concentration was targeted because it was within the range of values reported in brain tumor patients ().

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The production of O-desmethyl gefitinib has been shown, in vitro, to be via CYP2D6.

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IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy.

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This is an especially important aspect of care for those patients whose disease is not a good candidate for other forms of treatment.

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Chronic Myeloid Leukemia Patients to Assess Bioequivalence and Safety Evaluation of Generic Imatinib Mesylate 400 mg Tablets.

Any further trials in this setting should therefore include careful follow-up of all patients, particularly if the 400 mg bid regimen is utilized, and interim toxicity and safety analyses should be integrated into the study design.

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Management: These combinations are contraindicated during venetoclax initiation and ramp-up.

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Pruritus in patients treated with targeted cancer therapies: Systematic review and meta-analysis.

gefitinib and erlotinib offered very similar objective response rates of 27 and

However, it is not clear whether nuclear PKM2-induced STAT3 phosphorylation has a significant role in the regulation of gefitinib sensitivity in CRC.

Octreotide in the treatment of severe chemotherapy-induced diarrhea.

As expected, all the HER2-overexpressing gastric cancer cell lines exhibited high sensitivity to gefitinib both in vitro and in vivo.

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Surgery is the treatment of choice for early-stage localized disease, whereas multimodality therapy remains the norm for patients with locally advanced disease.

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The tumor response of the two dose groups averaged 10% (11.

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Consistent with these observations, we and two other groups revealed the essential role of EGFR mutations in lung carcinogenesis using transgenic mice.

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The important point is that the PFS and OS advantage seen in the Cappuzzo trial is largely driven by the EGFR wt patients who get a significant yet more modest benefit from maintenance EGFR TKI compared to the EGFR mutant population.

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Quality of life during maintenance therapy with pemetrexed was similar to placebo, except for a small increase in loss of appetite and significantly delayed worsening of pain and hemoptysis as assessed using the Lung Cancer Symptom Scale.

Hematological and biochemical testing and urinalysis were performed within 14 days of starting treatment.

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Mendelsohn J: Targeting the epidermal growth factor receptor for cancer therapy.

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Multicenter randomized, open-label phase II trial of sequential erlotinib and gemcitabine compared with gemcitabine monotherapy as first-line therapy in elderly or ECOG PS two patients with advanced NSCLC.

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Decision analyses demonstrate that FDG-PET scanning may reduce the overall costs of medical care by identifying patients with falsely negative CT scans in the mediastinum or otherwise undetected sites of metastases.

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If you become pregnant, discuss with your doctor the benefits and risks of using gefitinib during pregnancy.

So the SNP could be used as predictive marker for the genetic susceptibility to lung cancer according to their study.

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The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Dana-Farber researchers find that Gleevec, a targeted therapy that achieved striking success against chronic myelogenous leukemia, can shrink and even eliminate tumors in some patients with a rare and otherwise incurable digestive-tract cancer called gastrointestinal stromal tumor.

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Currently, we are running in a first-line setting the ZELIG (Zactima in NSCLC ELderly patients In combination with or versus Gemcitabine) phase II randomized trial of gemcitabine or gemcitabine plus vandetanib in untreated elderly NSCLC patients.

the calculated concentrations of erlotinib and gefitinib in blood

Sunitinib is approved for treatment of metastatic RCC.

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Finally, a Gompertz tumor growth model () was linked to the final PD model for each tumor group by using pERK as the biomarker.

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